The following 9 experts are listed against your chosen search criteria of:
Prof Mark Caulfield
My research interests include cardiovascular medicine, genetics of cardiovascular diseases, genetics of common diseases and hypertension. I also lead the MRC British Genetics of Hypertension Study, and am on the Steering group for 3 major Cardiovascular Outcome trials; ASCOT, Illuminate and Aviator.
Dr Caroline Brennan
I am interested in the molecular mechanisms controlling behaviour. I am particularly interested in endophenotypes associated with psychological disease, including drug addiction and dementia. I use zebrafish as our model system combining behavioural analysis, imaging and cell biology techniques in wild type, mutant and transgenic lines to investigate the neural correlates of reward and learning behaviours.
Dr Brendan Curran
With over 25 years of research experience in studying yeast, a model eukaryotic organism, my current research is focused on the molecular physiology of the yeast Heat Shock Response (HSR). Heat stress induces a subset of genes that encode protective proteins whenever living cells are exposed to a sub-lethal temperature shock. In 1994 we demonstrated that lipids play a vital role in how cells detect stress thereby successfully challenging the accepted paradigm that heat directly induced proteins to unfold - the latter then triggering the response. We have published a series of papers since then which demonstrate that lipids are also key players in conferring cross-tolerance between different types of stressing agents. More recently my group has concentrated on the role of Reactive Oxygen Species (ROS) in the HSR and we have published a number of papers implicating ROS as central to the cellular HS response mechanism. We have recently shown that lipids protect anaerobically-grown cells from HS-induced ROS thus relating lipids, ROS and the HSR.
Dr Yannick Wurm
Analyses genomes of auts to understand the roles of genes in the evolution of societies.
Prof Andrew Leitch
My group is interested in plant genetics, genomics, and cytogenetics, focussing on questions of an evolutionary and ecological nature. There is a focus on the processes and consequences of interspecific hybridisation and polyploidisation in plants, as well as an interest in the origin and ecological consequence of plant genome sizes.
Prof Patricia Munroe
My research is focused on elucidating the genetic and molecular basis of hypertension and cardiac arrhythmias. I co-lead several international complex genetic disease consortia. Using meta-analysis of genome-wide association studies (GWAS) and large-scale candidate gene studies I have discovered over 30 genetic loci associated with hypertension over the past 3 years.
Prof Joanne Martin
Histopathology; gene mapping; neurodegeneration; phenotype; myopathy; inclusion body; motor neuron disease; neuropathology. Gastrointestinal motility disorders.
Revpro Nicolas Goulding
My research interests lie in the area of glucocorticoid biology, with particular reference to the use of glucocorticosteroids in the treatment of inflammatory diseases such as rheumatoid arthritis. I also have interests in the ethics of medical research with a particular focus on the use of embryo-derived stem cells as therapeutics. The ethical, legal and social implications of the use of human embryos in medical research are complex and far-reaching. I lead a Halley-Stewart Trust-funded project to generate and assess the impact of novel educational materials for UK medical students in this rapidly developing area of medicine.
Prof Graham Hitman
My main research interests are directed to gene discovery arising from genome-wide association scans in type 2 diabetes and the use of epigenetics to study the gene environmental interaction. In addition to GIFTS, I am also one of the principal investigators of the CARDS (Collaborative Atorvastatin Diabetes Study) trial that has influenced the development of current lipid lowering guidelines in diabetes and am a principal investigator of two pilot diabetes prevention trials.