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Expertise: Autonomic physiology
Dr David Collier
I am now based at the Heart Centre at Barts, and ran the Anglo-Scandinavian Cardiac Outcome Trial (ASCOT) team for Professor Caulfield at Barts/London, which broke the national record for recruitment into such a trial (recruiting 1157 patients). As top academic recruiters for several studies across over a decade, which has contributed to high-impact work such as ILLUMINATE, with 148 patients (NEJM 2007 Barter, Caulfield et al ). ASCOT became a landmark trial and precipitated the development of joint NICE/BHS guidelines for hypertension after the publication of the Blood Pressure Lowering Arm (BPLA) in the Lancet in 2005 (prior to this time there had been separate NICE and BHS (British Hypertension Society) Guidelines on the treatment of hypertension in the UK- which had been unhelpful. ASCOT impacted the lipid guidance from NICE on statin use in primary prevention of ischaemic heart disease and stroke- bringing routine use of statins for people at elevated absolute risk, regardless of starting levels of cholesterol.