Experts Guide

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The following 12 experts are listed against your chosen search criteria of:
Expertise: Cells

Prof David Lee
I am an expert in cell and tissue engineering, in particular load-bearing tissues such as articular cartilage. I also conduct research on bio-ethics and law and biocompatibility testing.

Prof Wen Wang
My work encompasses biofluid mechanics, microcirculation, tissue deformation, gas exchange and osmoregulation.

Prof Martin Knight
My research is focussed on 'mechanobiology' or how living cells and tissues respond to physical forces. This includes the mechanical properties of living cells and tissues and the biological response. In particular I am interested in the role of the fascinating cellular structure known as the primary cilium (cilia in plural) and how this structure is involved in health and disease. I work with a variety of different cell types including cartilage cells, tendon cells, neurons and stem cells helping to understand important diseases such as osteoarthritis, tendonopathy and ovarian cancer.

Prof Rizgar Mageed
My studies are focussed on defining the molecular basis of humoral autoimmunity in patients with rheumatic diseases. These studies explore how abnormalities in intracellular signaling pathways in lymphocytes promote hyperactivity and autoimmunity. Other areas of research include stem-cell based gene therapy, antibody genes and intracellular signalling.

Dr Caroline Brennan
I am interested in the molecular mechanisms controlling behaviour. I am particularly interested in endophenotypes associated with psychological disease, including drug addiction and dementia. I use zebrafish as our model system combining behavioural analysis, imaging and cell biology techniques in wild type, mutant and transgenic lines to investigate the neural correlates of reward and learning behaviours.

Dr Brendan Curran
With over 25 years of research experience in studying yeast, a model eukaryotic organism, my current research is focused on the molecular physiology of the yeast Heat Shock Response (HSR). Heat stress induces a subset of genes that encode protective proteins whenever living cells are exposed to a sub-lethal temperature shock. In 1994 we demonstrated that lipids play a vital role in how cells detect stress thereby successfully challenging the accepted paradigm that heat directly induced proteins to unfold - the latter then triggering the response. We have published a series of papers since then which demonstrate that lipids are also key players in conferring cross-tolerance between different types of stressing agents. More recently my group has concentrated on the role of Reactive Oxygen Species (ROS) in the HSR and we have published a number of papers implicating ROS as central to the cellular HS response mechanism. We have recently shown that lipids protect anaerobically-grown cells from HS-induced ROS thus relating lipids, ROS and the HSR.

Dr Jurgen Groet
The long term theme underpinning my research is the study of chromosome and gene dose effects on cellular functions, specifically the phenotypic features of Down syndrome (DS). A particular interest of mine is to determine which chromosome 21 genes are involved in AMKL (a myeloid leukaemia with a 400 fold increased incidence in DS) and TMD (a transient precursor of AMKL, which is characterised by spontaneous remission).

Prof Dean Nizetic
One of my long term research themes is the study of chromosome and gene dose effects (aneuploidy and haploinsufficiency) on cellular functions, specifically the phenotypic features of Down syndrome (DS), caused by just one extra copy of perfectly normal, chromosome 21. Other research areas include childhood Leukemia, Alzheimer's disease, Neurodegeneration and studies of mouse embryonic stem cells.

Dr Rachel Ashworth
I conduct research in cell signalling during the development of an embryo, nerve and muscle development as well as imaging and fluorescence

Dr Gregory Michael
The function and characterisation of neural cells and response of these cells to injury; how neurons react to inputs such as temperature, mechanical force, pH and ATP levels in tissues, ultimately resulting in a perception of pain; which cells are involved and how each may respond to different stimuli or under different conditions (i.e. during inflammation); the relief of chronic pain; methods of stimulating neuronal recovery following injury.

Prof John Gribben
My primary research interests include the immunotherapy of cancer (including stem cell transplantation), the identification of B-cell-tumour antigens; and the detection and treatment of minimal residual disease in leukaemia and lymphoma.

Prof Anthony Mathur
I lead a collaborative group with Prof. John Martin (UCL) seeking to address the role of stem cells in the treatment of cardiovascular disease. My research in interventional cardiology is targeted at the no-option patient with the aim of developing new techniques and devices to treat patients that fall outside the remit of current recognised therapies.

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