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The following 23 experts are listed against your chosen search criteria of:
Expertise: Diseases

Prof Thomas Macdonald
Research interests include gut immunology, in particular the immune mechanisms responsible for Crohn's Disease, ulcerative colitis and coeliac disease; and new treatments which might cure these diseases.

Dr David Wareham
My current research interests include the molecular epidemiology, mechanisms of resistance and pathogenicity of Gram-negative nosocomial pathogens. Other areas in which I specialise are antimicrobial research, infection in critical care, infection in cystic fibrosis and clinical microbiology.

Prof David Wald
I am undertaking research into the prevention of cardiovascular disease. My clinical/academic aims are to bridge the interventional and preventive approaches to cardiovascular disease which are often viewed as distinct. Other interests include screening for familial hypercholesterolaemia, hypertrophic cardiomyopathy and the effect of folic acid on cardiovascular disease.

Dr John Viles
I have an active research program studying protein misfolding associated with amyloid formation in neurodegenerative diseases such as Alzheimer's. My team uses a range of biophysical techniques to study the fundamental process that influence neurotoxic oligomer and amyloid plaque formation. Approaches include, bimolecular spectroscopies, including NMR, CD, IR and EPR to study protein structure, misfolding and stability.

Prof Ian Sanderson
My work has centered on the nutritional effect on gene expression in the intestine. This has extended to research on nutritional regulation of genes, Crohn's disease, dietary therapy, antigen presentation in the intestinal epithelium and chemokines in intestinal inflammation.

Prof David Kelsell
My work primarily focuses on the molecular mechanisms underlying primarily inherited monogenic disease. New studies include the identification of the first human ADAM17 mutations (underlie inflammatory bowel and skin disease) plus the identification of the genetic cause of a familial form of susceptibility to oesophageal cancer called "Tylosis" - members have a very high risk of developing squamous cell cancer of the oesophagus (up to 95% by age 65).

Prof Michael Curtis
My main research interests are the mechanisms by which bacteria cause human disease with special reference to periodontal disease. Other interests include microbial pathogenesis, periodontal disease, bacterial proteases, host-parasite interactions, oral microbiology and molecular microbiology.

Prof Frances Balkwill
I am interested in cancer development and spread, as well as ovarian cancer. I also conduct research on HIV/Aids and specialise in science communication and engagement with children.

Prof Lucinda Hall
My research interests centre on the evolution of bacterial pathogens, particularly in relation to antibiotic resistance. Other projects relate to the genetic mechanisms of mutation in Streptococcus pneumoniae, particularly in relation to the evolution of multiresistant strains with international spread. A developing area of research is in the microbiota of the gut and its interaction with the host in health and disease, in collaboration with groups within and outside the Centre.

Prof Graham Hitman
My main research interests are directed to gene discovery arising from genome-wide association scans in type 2 diabetes and the use of epigenetics to study the gene environmental interaction. In addition to GIFTS, I am also one of the principal investigators of the CARDS (Collaborative Atorvastatin Diabetes Study) trial that has influenced the development of current lipid lowering guidelines in diabetes and am a principal investigator of two pilot diabetes prevention trials.

Prof Dean Nizetic
One of my long term research themes is the study of chromosome and gene dose effects (aneuploidy and haploinsufficiency) on cellular functions, specifically the phenotypic features of Down syndrome (DS), caused by just one extra copy of perfectly normal, chromosome 21. Other research areas include childhood Leukemia, Alzheimer's disease, Neurodegeneration and studies of mouse embryonic stem cells.

Prof Mauro Perretti
I have conducted research on the following: pharmacology; inflammation; vascular inflammation; drug development; glucocorticoids; anti-inflammatory mediators; leukocyte recruitment.

Prof Roger Corder
My research focuses on identification of biomarkers of disease for the early diagnosis of patients before symptoms develop, and which also respond to treatment so that they can be used as surrogate outcome measures in clinical trials. I conduct clinical trials of dietary polyphenols to develop an evidence-based approach to improving vascular health or reducing diabetes through optimised foods and nutraceutical products. I also work on the characterisation of cellular and molecular actions of dietary polyphenols in order to define targets for future drug development.

Dr Martin Carrier
My research focuses on molecular pharmacology of cardiovascular disease associated with atherosclerosis and type 2 diabetes. I am also interested in the role of oxidative stress and endothelial function in these processes.

Prof Nicholas Wald
My research interests include epidemiology, public health, and screening (ante-natal, cancer, cardio-vascular). I am the innovator of the "Polypill", a new approach to the primary prevention of cardiovascular disease, and with my son David have conducted a trial demonstrating the expected effect of a polypill. I have also worked on primary prevention of serious disorders such as neural tube defects and lung cancer. I have pioneered research on the benefits of Folic Acid during pregnancy, as well as the Barts Triple Test for early detection of Down's syndrome.

Prof Graham Foster
I have a long standing interest in the management of chronic viral hepatitis and run a clinical research program studying the natural history of viral hepatitis, its impact upon patients and their communities and novel therapies for this disease. I supervise a laboratory research program investigating the basic virology of hepatotropic viruses novel replication models for hepatitis C.

Prof Robert Allaker
Host/microbial interactions and antimicrobial research have provided the focus for my career.These areas include skin and oral infections; periodontal diseases in man and animals; innate immunity; Nitric Oxide; antimicrobial peptides; oral bacteria and systemic disease.

Dr Kambiz Boomla
I am interested in sharing quality in data as well as setting up disease registers.

Prof Mark Caulfield
My research interests include cardiovascular medicine, genetics of cardiovascular diseases, genetics of common diseases and hypertension. I also lead the MRC British Genetics of Hypertension Study, and am on the Steering group for 3 major Cardiovascular Outcome trials; ASCOT, Illuminate and Aviator.

Prof Christopher Griffiths
My main research interests include asthma, COPD, TB, allergy, diabetes, vitamin D, primary care, clinical trials, and qualitative research.

Prof Richard Leslie
Diabetes; immunology; metabolism; epidemiology.

Dr Satya Das
My research interests include infection imaging, infection in immunocompromised patients, Tuberculosis, endocarditis and systemic fungal infections.

Prof Aine Mcknight
My research has broadly focused on investigating the development of an HIV vaccine. I focus mainly on the interface between HIV and the immune system with regard to adaptive humoral and innate immunity. I described an innate immune mechanism (Lv-2) that inhibits HIV replication after cellular entry resulting in abortive infection. My group mapped two viral genes to be involved in overcoming this antiviral effect.

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